NCT01878643

Reduction of Bacterial Resistance With Inhaled Antibiotics in the Intensive Care Unit

Pilot Study of the Effects of Inhaled Antibiotic on Bacterial Resistance

• Status: Completed
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 47 (actual)
• Sponsor: Stony Brook University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study was : * to determine the effect of inhaled antibiotics on airway bacteria in ventilated patients * to determine the effect of inhaled antibiotics on respiratory infection

Detailed description

Double-blind randomized placebo controlled study examining the effect of aerosolized antibiotics on respiratory infection signs and symptoms and on bacterial eradication and resistance. Systemic antibiotics are administered by the responsible physician

Conditions

• Respiratory Infection
• Bacterial Resistance
• Respiratory Failure

Interventions

Type	Name	Description
DRUG	vancomycin or gentamicin	Choice of antibiotic is determined by Gram stain of sputum.The antibiotic is administered via nebulization through the ventilator circuit every 8 hours
DRUG	Placebo	normal saline administered to patient via nebulization

Timeline

• Start date: 2001-12-01
• Primary completion: 2002-12-01
• Completion: 2002-12-01
• First posted: 2013-06-17
• Last updated: 2013-06-17

Locations

1 site across 1 country: United States