NCT01866982

The PREMOD Trial: A Randomized Controlled Trial of Umbilical Cord Milking vs. Delayed Cord Clamping in Premature Infants

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 197 (actual)
• Sponsor: Sharp HealthCare · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

Premature babies can be very sick and have bleeding in the brain. Giving babies more blood before cutting the umbilical cord by delayed cord clamping or umbilical cord milking has been shown to reduce the risk of bleeding in the brain. This may be related to improving perfusion to the brain. However, some studies suggest that delayed cord clamping may not increase hemoglobin or blood volume in babies delivered by cesarean section. Milking the umbilical cord may give more blood in babies delivered by Cesarean Section may improve perfusion and reduce bleeding in the brain.

Conditions

• Intraventricular Hemorrhage

Interventions

Type	Name	Description
PROCEDURE	Umbilical Cord Milking	Umbilical cord milked toward the neonate four times at a speed of 20cm/2seconds, prior to clamping and cutting umbilical cord. Procedure takes about 10-20 seconds.
PROCEDURE	Delayed Cord Clamping	Performed by positioning the baby 20 cm below the placenta for 45-60 seconds prior to umbilical cord clamping and cutting.

Timeline

• Start date: 2013-07-02
• Primary completion: 2014-12-01
• Completion: 2018-01-10
• First posted: 2013-06-03
• Last updated: 2018-05-24

Locations

3 sites across 1 country: United States