NCT01864317

Assessment of Optic Nerve Radiation in Patients With Glaucoma and Ocular Hypertension by 7 Tesla Diffusion Tensor Imaging

• Status: Terminated
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 120 (estimated)
• Sponsor: Medical University of Vienna · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Glaucoma is among the leading causes for blindness in the western world. Elevated intraocular pressure (IOP) has been identified as the most important risk factor. However, some patients progress despite adequate IOP lowering while some subjects with elevated IOP never develop glaucoma. Other patients develop glaucoma although IOP measurements were always in the normal range. Therefore, other factors must be involved. In the last years, studies using MRI have been performed and evidence has accumulated that also changes in retrobulbar structures are present, in particular in the lateral geniculate nucleus and the visual cortex. However, these studies were limited by the low spatial resolution of the MRI instruments used. The investigators propose to overcome this problem by using an ultrahigh-field Magnetom 7T whole-body MR scanner (Siemens Medical, Germany) installed at the MR Centre of Excellence at the Medical University of Vienna. This scanner is equipped with a 32-channel head coil and the SC72 high-performance gradient system and is thus perfectly suited for structural and functional imaging. The aim of the present study is to investigate whether structural and functional parameters are altered in patients with primary open angle glaucoma (POAG), normal tension glaucoma (NTG), ocular hypertension (OHT) compared to healthy control subjects. The exact topographical survey of intracranial structures such as the LGN and the assessment of neuronal structures by DTI may allow for the better assessment of therapeutic responses to new neuroprotective agents.

Conditions

• Primary Open Angle Glaucoma
• Ocular Hypertension
• Normal Tension Glaucoma

Interventions

Type	Name	Description
DEVICE	7-Tesla MRI	High resolution functional and structural imaging of the visual pathway
OTHER	Optical Coherence Tomography	Measurement of retinal nerve fiber thickness
OTHER	Heidelberg Retina Tomography	Measurement of retinal nerve fiber thickness
OTHER	Scanning Laser Polarimetry	Measurement of retinal nerve fiber thickness
OTHER	Humphrey Perimetry	Visual Field Testing
OTHER	Applanation Tonometry	Measurement of Intraocular Pressure

Timeline

• Start date: 2015-11-01
• Primary completion: 2015-12-01
• Completion: 2015-12-01
• First posted: 2013-05-29
• Last updated: 2019-08-22

Locations

1 site across 1 country: Austria