NCT01854021

Effects of Different General Anesthesia Methods on Immune Responses in Patients Undergoing Surgery for Tongue Cancer

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: tiejun Zhang · Academic / Other
• Sex: All
• Age: 50 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

Surgical excision is the mainstay of treatment for tongue cancer. However, surgery-induced immunosuppression has been implicated in the development of post-operative septic complications and neoplasm metastasis. General anesthesia is considered to not only suppress surgical stress, but also affect the immune function directly，such as altering the number and activity of immune cells. It is reported that some anesthetics increase susceptibility to tumor metastasis, apparently by suppressing natural killer cell activity. Different anesthetic techniques and anesthetics used in anesthesia have shown different effects on immunity. Many of the studies were animal trials or performed in vitro; in addition, most are focused on a single drug. To date, there is little published prospective clinical research designed specifically to investigate the effects of different general anesthetic technique on immune function in patients with oral malignant tumors. The aim of this study is going to characterize the immune response of patients undergoing surgery for tongue cancer under 3 types of general anesthesia.

Conditions

• Tongue Cancer

Interventions

Type	Name	Description
PROCEDURE	intravenous anesthesia	intravenous anesthesia
PROCEDURE	combined intravenous-inhalational anesthesia	combined intravenous-inhalational anesthesia
PROCEDURE	inhalational anesthesia	inhalational anesthesia

Timeline

• Start date: 2013-05-01
• Primary completion: 2013-08-01
• First posted: 2013-05-15
• Last updated: 2013-05-17

Locations

1 site across 1 country: China