NCT01822587

Enhancing Disrupted Reconsolidation: Impact on Cocaine Craving

Enhancing Disrupted Reconsolidation: Impact on Cocaine Craving, Reactivity and Use

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 181 (actual)
• Sponsor: Medical University of South Carolina · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The investigators' recently completed study has provided the first evidence that administration of the medication propranolol, following exposure to cocaine cues, can alter drug-associated memories and reduce craving and other drug cue-elicited responses in cocaine addicted persons. The investigators will attempt to augment this effect by a) doubling the number of propranolol-medicated cocaine cue exposure (CCE) retrieval sessions and b) increasing the dose of propranolol. It is expected that propranolol treated groups, relative to placebo treated groups, will evidence greater reduction of craving, cue reactivity and cocaine use during follow-up cocaine cue exposures. Also, these effects will be greater for those who receive 80mg of propranolol as opposed to 40mg.

Detailed description

Three groups of CD (cocaine dependant) participants will receive two sessions of cocaine cue exposure (CCE), each separated by a 24 hr. period and both conducted while the participants remain in hospital. One group (PBO) will receive placebo following each CCE session while the second (40PP) and third (80PP) group will receive 40 mg and 80 mg propranolol, respectively. Participants will return two days, and 1, 3, and 6 weeks after discharge and will be administered a CCE session to assess for maintenance/generalization of disruption of reconsolidation (DoR) effects on craving and cue reactivity to familiar and novel cocaine cues. Participants will also be assessed 3 times weekly for cocaine use (self-report \& urine drug screen) during follow-up.

Conditions

• Cocaine Addiction

Interventions

Type	Name	Description
DRUG	Propranolol, 40 mg
DRUG	Propranolol, 80 mg
DRUG	Placebo

Timeline

• Start date: 2013-09-01
• Primary completion: 2018-11-05
• Completion: 2018-11-05
• First posted: 2013-04-02
• Last updated: 2019-12-26
• Results posted: 2019-12-17

Locations

1 site across 1 country: United States