NCT01820507

Extubation Failure Prevention in High Risk Patients by High-flow Conditioned Oxygen Therapy vs. Standard Oxygen Therapy

Prevention of Post-extubation Respiratory Failure in High Risk Patients by High-flow Conditioned Oxygen Therapy Versus Standard Oxygen Therapy

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 155 (actual)
• Sponsor: Althaia Xarxa Assistencial Universitària de Manresa · Academic / Other
• Sex: All
• Age: 18 Years – 95 Years
• Healthy volunteers: Not accepted

Summary

Failure of extubation after mechanical ventilation is a frequent and deleterious issue. Main reasons for failure are hypoxemia, secretions retention, lung collapse and excessive work of breathing. Most of this issues can be partly counterbalanced by a device named "High flow conditioned oxygen therapy (HFCO)". Then, our hypothesis is that HFCO may reduce the incidence of respiratory failure after extubation in patients with high risk for failure.

Conditions

• Respiratory Failure

Interventions

Type	Name	Description
DEVICE	Optiflow (Fisher&Paykel)	The described method of oxygen supply will be maintained continuously for the first 24 hours after extubation.
DEVICE	Nasal cannulae or controlled oxygen concentration mask	The described method of oxygen supply will be maintained continuously for the first 24 hours after extubation.

Timeline

• Start date: 2013-03-01
• Primary completion: 2014-11-01
• Completion: 2015-01-01
• First posted: 2013-03-28
• Last updated: 2015-01-30

Locations

1 site across 1 country: Spain