NCT01818453

Can Genetics Predict Treatment Response to a Computerized Self-help Program for Depression?

Genetic Predictors of Response to a Computerized Self-help Program for Depression

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 500 (estimated)
• Sponsor: University of Texas at Austin · Academic / Other
• Sex: All
• Age: 18 Years – 55 Years
• Healthy volunteers: Not accepted

Summary

The goal of this project is to determine whether genetic information can be used to predict response to an internet-based treatment of depression. Several studies now indicate that completing an internet-based treatment for depression, called Deprexis, can significantly improve symptoms of depression. However, not everyone improves. The purpose of this study is to determine whether genetic profile can predict who is likely to improve.

Conditions

• Major Depressive Disorder
• Mood Disorders

Interventions

Type	Name	Description
BEHAVIORAL	Computerized self-help program for depression	For 8 weeks, participants will engage in a computerized self-help program for depression, called deprexis. This program consists of 10 content modules representing different psychotherapeutic approaches broadly consistent with a cognitive-behavioral perspective. Modules are organized as simulated dialogues in which the program explains and illustrates concepts and techniques, engages the user in exercises, and continuously asks users to respond by selecting from response options. Subsequent content is then tailored to the users' responses, resulting in a simulated conversational flow. Participants can access the self-help program as often as they would like and since it is self-guided, they will determine how often they access the material. Each module can be completed in 10 to 60 minutes, depending on the user's reading speed, interest, motivation, and individual path through the program.

Timeline

• Start date: 2013-03-01
• Primary completion: 2015-11-01
• Completion: 2015-11-01
• First posted: 2013-03-26
• Last updated: 2015-11-09

Locations

1 site across 1 country: United States