NCT01815112

Early Diagnosis of Alzheimer-like Dementia: Benefit of MRI and PET Imaging

Benefit of MRI and 18F-FDG PET Imaging in the Early Diagnosis of Alzheimer-like Dementia

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: Centre Hospitalier Universitaire, Amiens · Academic / Other
• Sex: All
• Age: 65 Years
• Healthy volunteers: Accepted

Summary

The physio-pathology of Alzheimer's disease (AD) remains unknown and there is no cure. Thus, the search for objective markers of preclinical first signs of cognitive impairment, is currently a major public health issue. Early detection of the disease is a major challenge to hope to slow or even stop the neurodegenerative process before the stage of dementia. In AD the investigators observe: * A reduction in the volume of brain hippocampi associated with an alteration of the diffusion of water molecules in the white matter. * A structural brain degeneration coupled with a decrease in cerebral glucose metabolism. Recent publications show that cerebrospinal fluid (CSF)flow is also altered, probably due to dysfunction of the choroid plexus. Hence the potential interest to study is, in addition to conventional imaging, the imaging of CSF dynamics and choroid plexus metabolism. In that aim,the investigators use two imaging modalities: * Magnetic resonance imaging (MRI) is used to assess blood and CSF flow in the brain * Positron emission tomography (PET) is used to assess glucose metabolism in grey/white matter and also in choroid plexus. The investigators expect that, because of choroid plexus atrophy in AD, CSF flow would be altered as well as glucose metabolism dynamic in choroid plexus.

Conditions

• Alzheimer Disease
• Mild Cognitive Impairment
• Vascular Dementia

Interventions

Type	Name	Description
OTHER	Magnetic resonance imaging	CSF flow measurement at Sylvius' aqueduct and cervical levels. Apparent diffusion coefficient and fractional anisotropy determination in corpus callosum, cingulum and hippocampus.
OTHER	Positron emission tomography	Tissue-time activity curves in hippocampus, cingulum, medio-temporal cortex and choroid plexus.

Timeline

• Start date: 2008-02-01
• Primary completion: 2013-04-01
• Completion: 2014-04-01
• First posted: 2013-03-20
• Last updated: 2015-03-10

Locations

2 sites across 1 country: France