NCT01804283

Effects of Ischemic Postconditioning on MicroRNAs in Double Valve Replacement

Effects of Ischemic Postconditioning on Expression of Apoptosis-related MicroRNAs and Genes in Human Double Valve Replacement

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 8 (estimated)
• Sponsor: Central South University · Academic / Other
• Sex: All
• Age: 20 Years
• Healthy volunteers: Not accepted

Summary

1. Cardiopulmonary bypass and cardioplegic arrest could regulate expression of microRNAs in patients undergoing double valve replacement (aortic and mitral). 2. The modulation of myocardial microRNAs by cardiopulmonary bypass and cardioplegic arrest may be rescued by ischemic postconditioning. 3. Downstream effectors would also be affected.

Conditions

• Cardiopulmonary Bypass
• Ischemic Postconditioning

Interventions

Type	Name	Description
PROCEDURE	ischemic postconditioning	multiple brief ischemic-reperfusion episodes immediately after sustained ischemic insult Postconditioning was started at 30 s after aortic cross declamping, and the aorta was re-clamped for 30 s rendering global myocardial ischemia. Meanwhile aortic root suction was established during aortic re-clamping, and thereafter, the aortic clamp was released for 30 s for full myocardial reperfusion. The cycle was repeated three times after cardioplegic arrest.
PROCEDURE	double valve replacement	The double valve replacement is a procedure in which surgery is used to replace diseased aortic and mitral heart valves.
DEVICE	heart-lung machine	The heart-lung machine is commonly used in open heart surgery including double valve replacement to support the circulation during the operation.
DEVICE	Aortic cross-clamp	a surgical instrument used in cardiac surgery to clamp the aorta

Timeline

• Start date: 2013-03-01
• Primary completion: 2013-03-01
• First posted: 2013-03-05
• Last updated: 2013-03-05

Locations

1 site across 1 country: China