Trials / Completed
CompletedNCT01782586
Validation of Gene Expression Markers of Renal Allograft Functional Decline
Multicenter Validation of Gene Expression Markers of Renal Allograft Functional Decline (GEN-04)
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 499 (actual)
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID) · NIH
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
The purpose of this study is to determine if certain genes found in a kidney biopsy performed at one-year post transplant can predict which transplanted kidneys will have decreased kidney function within five years post-transplant.
Detailed description
Gene expression profiling is used to study the activity of genes. Each gene has an "on/off" switch that controls how they are expressed in a cell, as well as a "volume control" that increases or decreases the level of expression of a particular gene as necessary. Researchers want to see if the presence and abundance of certain transcripts in a kidney biopsy at one year after transplant can predict which kidneys will have reduced function over time.
Conditions
Timeline
- Start date
- 2013-03-01
- Primary completion
- 2018-03-01
- Completion
- 2018-03-01
- First posted
- 2013-02-04
- Last updated
- 2019-10-04
Locations
4 sites across 1 country: United States
Source: ClinicalTrials.gov record NCT01782586. Inclusion in this directory is not an endorsement.