Trials / Completed
CompletedNCT01780675
Hippocampus Avoidance PCI vs PCI
Prophylactic Cranial Irradiation With or Without Hippocampal Avoidance in SCLC a Randomized Phase III Trial
- Status
- Completed
- Phase
- Phase 3
- Study type
- Interventional
- Enrollment
- 168 (actual)
- Sponsor
- The Netherlands Cancer Institute · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
Using Intensity Modulated radiotherapy it is possible to treat the entire brain to standard dosages of whole-brain radiation, while keeping the radiation dose to the hippocampus low. However, a clear relationship between radiation dose and damage to the hippocampal stem cells has not been established yet. This study is initiated to investigate the early and delayed neurotoxicity of PCI and to assess in a randomised design the benefits and risks of sparing the hippocampus in Small Cell Lung Cancer patients who receive PCI.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| RADIATION | Radiation Prophylactic Cranial Irradiation | |
| RADIATION | Radiation Hippocampal Avoidance PCI |
Timeline
- Start date
- 2013-04-01
- Primary completion
- 2019-04-01
- Completion
- 2022-01-01
- First posted
- 2013-01-31
- Last updated
- 2022-01-21
Locations
9 sites across 2 countries: Belgium, Netherlands
Source: ClinicalTrials.gov record NCT01780675. Inclusion in this directory is not an endorsement.