NCT01779284

Travoprost/Timolol vs Latanoprost/Timolol Fixed Combination Therapy

24-Hour Efficacy of Travoprost/Timolol Benzalkonium Chloride BAK Free Compared With Latanoprost/Timolol Fixed Combination Therapy in Subjects With Open-Angle Glaucoma Insufficiently Controlled With Latanoprost Monotherapy

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 42 (actual)
• Sponsor: Aristotle University Of Thessaloniki · Academic / Other
• Sex: All
• Age: 29 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The primary objective of this crossover trial is to compare the 3-month, mean 24-hour intraocular pressure (IOP) control and safety obtained with two popular fixed combinations in glaucoma patients insufficiently controlled with latanoprost monotherapy. This study will compare the 24-hour efficacy of travoprost/timolol fixed combination without benzalkonium chloride given once in the evening, versus the latanoprost/timolol fixed combination given in the evening. It is assumed that travoprost/timolol fixed combination will provide better quality of 24-hour pressure control.

Conditions

• Glaucoma

Interventions

Type	Name	Description
DRUG	Travoprost/timolol therapy	Evaluation of 24-hour pressure efficacy with travoprost/timolol therapy after 3 months of chronic dosing
DRUG	Latanoprost/Timolol therapy	Evaluation of 24-hour pressure efficacy for this drug after 3 months of chronic therapy

Timeline

• Start date: 2012-01-01
• Primary completion: 2012-12-01
• Completion: 2013-01-01
• First posted: 2013-01-30
• Last updated: 2014-05-12

Locations

1 site across 1 country: Greece