NCT01749696

Alterations in Connective Tissue in Patients With or Without Pelvic Organ Prolapse

Alterations in Connective Tissue in Patients With or Without Pelvic Organ Prolapse.

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 78 (actual)
• Sponsor: Turku University Hospital · Other Government
• Sex: Female
• Age: —
• Healthy volunteers: Not accepted

Summary

The aim of our study is to investigate the alterations in connective tissue of vaginal wall in patients with and without pelvic organ prolapse (POP).

Detailed description

The tissue samples were taken from the anterior wall of vagina in the midline close to cervix or apex. The tissue samples were collected from the vaginal wall of the patients with pelvic organ prolapse (n=39) during vaginal prolapse surgery. Control samples (n=39) were taken from patients after vaginal or laparoscopic removal of the uterus. The formalin-fixed and paraffin embedded tissue samples were stained with Verhoeff van Gieson and Movat's pentachrome. Samples were examined by pathologist and gynecologist blinded as to the other investigator and to the pelvic organ prolapse status. In case of discrepancy investigators evaluated the samples together to gain consensus.

Conditions

• Pelvic Organ Prolapse

Timeline

• Start date: 2009-11-01
• Primary completion: 2012-09-01
• Completion: 2014-04-01
• First posted: 2012-12-17
• Last updated: 2014-05-09

Locations

1 site across 1 country: Finland