NCT01748136

Screening for Lung Cancer in the HIV Patient

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 200 (actual)
• Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Academic / Other
• Sex: All
• Age: 26 Years – 100 Years
• Healthy volunteers: Not accepted

Summary

That computed tomography (CT) screening of HIV-seropositive heavy smokers will detect early stage lung cancer at significantly higher rates than what is currently being observed.

Detailed description

The study design is that of a prospective cohort study in which 200 smoking participants will be recruited from an existing HIV-seropositive cohort of 800 patients (the Human Oral Papillomavirus Etiology (HOPE) Study). Participants will be enrolled from the Johns Hopkins HIV (Moore) Clinic and the resources of the Johns Hopkins Adult Outpatient General Clinical Research Center (GCRC) and pilot project funding from the Lung Cancer SPORE will be utilized to fund the costs of the CT scans. An interdisciplinary team with expertise in HIV-associated malignancy, CT screening, lung cancer surgery, HIV infection, epidemiology and biostatistics has been assembled to test the hypothesis by accomplishing the following Specific Aims:

Conditions

• Lung Cancer in the HIV Patient
• HIV Infections
• HIV Seropositivity
• Lung Cancer

Interventions

Type	Name	Description
DEVICE	CT Scan with Spirometry	During the screening and later during the five annual study visits the patients will be scheduled to undergo total of five CT scans. The first CT scan will take place at the beginning of the study and then each year for a period of five years.

Timeline

• Start date: 2006-01-01
• Primary completion: 2011-09-01
• Completion: 2011-09-01
• First posted: 2012-12-12
• Last updated: 2019-03-28