NCT01737606

Ultrasonic Explorations of Cerebral Tissue Motions - Influence of Aging

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 53 (actual)
• Sponsor: University Hospital, Tours · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The new technical of ultrasonic exploration of this project purpose to validate the measurement of cerebral pulsatility by a new way called "Fast Cerebral Pulsatility Imaging" (FCPI).This will somehow determine the natural history of cerebral pulsatility during development adult to old age

Detailed description

Main objective Phase 1: -Study the in-vivo development of ultrasonic method in terms of quality of the acquisitions and intra-operator reproducibility. Study the ease of positioning in relation to MRI and fusion of MRI and FCPI data via the neuro-navigation system Phase 2: -Study the variability of cerebral pulsatility of measured by "Fast Cerebral Pulsatility Imaging" or FCPI with age. Secondary objectives * Compare the results of displacements cartography's and vascular cartography obtained by MRI (especially by Arteriel Spin Labelling = ASL) * Compare results of FCPI with results of cognitive tests of aging separating fluid functions (prefrontal) and functions called crystallized; and study the residual effect of age on cognitive tasks and speed of cognitive processing after taking into account the effect of the cerebral pulsatility * Compare results of FCPI with electrophysiological measures (PE EEG) describing the attentional control * Perform an exploratory analysis to highlight the propagating part of the brain displacement maps

Conditions

• Aging
• Cerebral Pulsatility

Interventions

Type	Name	Description
DEVICE	Fast Cerebral Pulsatility Imaging	Cerebral ultrasonic exploration using with neuro-navigation system : 4 acquisitions on 12 or 6 section planes

Timeline

• Start date: 2012-09-01
• Primary completion: 2013-06-01
• Completion: 2013-07-01
• First posted: 2012-11-29
• Last updated: 2025-12-23

Locations

1 site across 1 country: France