Trials / Completed
CompletedNCT01726764
Interaction Between St John's Wort and Metformin?
Is There a Pharmacokinetic Interaction Between St John's Wort and Metformin?
- Status
- Completed
- Phase
- Phase 1
- Study type
- Interventional
- Enrollment
- 20 (actual)
- Sponsor
- University of Southern Denmark · Academic / Other
- Sex
- Male
- Age
- 18 Years – 64 Years
- Healthy volunteers
- Accepted
Summary
The goal of the study is to examine the difference of the pharmacokinetics of metformin with and without a 3 weeks pretreatment of St John's Wort. Furthermore secondary objectives include changes in GLP-1, C-peptide, serum-insulin and plasma-glucose during an oral glucose tolerance test, changes in OCT1 mRNA in plasma and changes in leptin and lipid-profile following this possible interaction.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | St John's Wort | |
| DRUG | Metformin |
Timeline
- Start date
- 2013-01-01
- Primary completion
- 2013-06-01
- Completion
- 2014-05-01
- First posted
- 2012-11-15
- Last updated
- 2014-12-03
Locations
1 site across 1 country: Denmark
Source: ClinicalTrials.gov record NCT01726764. Inclusion in this directory is not an endorsement.