NCT01722422

Hyperoxia and Hypertonic Saline in Septic Shock

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 441 (actual)
• Sponsor: University Hospital, Angers · Other Government
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Assessment of the effect of hyperoxia and hypertonic saline on survival in patients with septic shock Hyperoxia and hypertonic saline may have beneficial effects on organ perfusion and oxygenation and may reduce the organ failure occurences. To date, only scarce data are available. Side effects are not well described. Therefore we designed a randomized clinical trial in order to assess the early administration of hypertonic saline and oxygen in the very early beginning of septic shock.

Detailed description

The study is designed as factorial 2x2. Patients will be stratified at the randomisation according the presence or absence of Acute Respiratory Distress Syndrome in order to perform a sub group analysis for all outcome criteria.

Conditions

• Septic Shock
• Adult Respiratory Distress Syndrome

Interventions

Type	Name	Description
DRUG	oxygen and saline

Timeline

• Start date: 2012-10-01
• Primary completion: 2014-09-01
• Completion: 2014-09-01
• First posted: 2012-11-06
• Last updated: 2014-11-20

Locations

1 site across 1 country: France