NCT01720693

Novel Controlled Hypo-Perfusion Technique in Partial Nephrectomy

A Pilot Study to Examine a Novel Controlled Hypo-Perfusion Technique in Partial Nephrectomy

• Status: Terminated
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 3 (actual)
• Sponsor: University Health Network, Toronto · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

Many patients who are candidates for nephron-sparing surgery, partial nephrectomy is now the standard treatment with a surgical, small, clinical T1 tumor (\<7 cm). In many recent studies, partial nephrectomy provides equivalent oncologic, and superior functional, outcomes compared with the standard radical nephrectomy over the short and long term (2, 3). Partial nephrectomy techniques, whether open, laparoscopic or robotic, typically involve hilar clamping, which creates the desired bloodless operative field, allowing for more precise tumor excision and renal reconstruction. This hilar clamping eventually may lead to ischemic kidney injury which can compromise the functional outcomes of the remaining kidney.We are working now to develop a novel technique of Hypo-Perfusion by achieving partial renal arterial clamping, with the goal of completely eliminating surgical ischemia to the renal remnant.

Conditions

• Partial Nephrectomy
• Renal Cell Carcinoma

Interventions

Type	Name	Description
PROCEDURE	Hypoperfusion of renal artery	The renal artery is occluded to 30% of it's baseline, prior to kidney tumour removal

Timeline

• Start date: 2012-06-01
• Primary completion: 2014-11-01
• Completion: 2014-12-01
• First posted: 2012-11-02
• Last updated: 2015-02-11

Locations

1 site across 1 country: Canada