NCT01713205

Prediction Study of Complications After Severe Trauma

Identifying Severe Trauma Patients at High Risk of Post-traumatic Complications

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 3,500 (estimated)
• Sponsor: Jiang Jianxin · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to evaluate a clinically and economically most effective diagnostic algorithm for prediction of post-traumatic complications in a multicenter sample of severe trauma patients.

Detailed description

Trauma is a major public health problem worldwide, ranking as the fourth leading cause of death. One of the most serious complications of major trauma is sepsis, which often induces sequential multiple organ dysfunction syndrome (MODS). There were still no specific biomarkers to predict the susceptibility of complications and outcomes, which leading to the limited prevention methods and the high mortality rate of severe trauma patients. Previous studies from our and other group have found some sepsis and MODS predictors, including genetic polymorphisms, serum cytokines and cell-surface markers. The purposes of this multi-center observational study is to select biomarkers and evaluate a clinically and economically most effective diagnostic algorithm for prediction of complications in severe trauma patients.

Conditions

• Trauma
• Sepsis
• Multiple Organ Dysfunction Syndrome

Timeline

• Start date: 2012-10-01
• Primary completion: 2023-12-01
• Completion: 2023-12-01
• First posted: 2012-10-24
• Last updated: 2022-08-01

Locations

6 sites across 1 country: China