NCT01700907

Optimization of Desflurane in Elderly Patients

Optimization of Desflurane in Elderly Patients Compared With Sevoflurane: A Pilot Study

• Status: Completed
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: Sapporo Medical University · Academic / Other
• Sex: All
• Age: 65 Years
• Healthy volunteers: Not accepted

Summary

Various issues had been pointed out when undergoing the anesthesia for elderly patients with sevoflurane, such as delayed emergence, post-operative trouble with swallowing. Desflurane, which has a lower blood/gas partition coefficient, is expected to contribute the better emergence, along with the recent progress on optimization of delivered amount of anesthesia. The purpose of this study is to compare the time to emergence in long elderly patient cases with desflurane or sevoflurane, with the recently developed drug-delivery optimization system "Aisys®" (GE Healthcare Japan).

Detailed description

The objectives of this study is to compare the time to emergence and quality of recovery in long elderly patient cases with desflurane or sevoflurane, with the recently developed drug-delivery optimization system "Aisys®" (GE Healthcare Japan). Inclusion Criteria: \- Elderly patients (\>= 65 yr-old), long operation (\> 4hours), abdominal surgery patients Exclusion Criteria: \- Liver dysfunction, Renal dysfunction, preoperative dementia Neurosurgery patients, Cardiac surgery patients, obese patients(BMI\>35)

Conditions

• Postoperative Cognitive Dysfunction

Interventions

Type	Name	Description
DRUG	Desflurane	The patients in this arm will be given the general anesthesia with desflurane and be used the Aysis as the anesthetic machine.
DRUG	Sevoflurane	The patients in this arm will be given the general anesthesia with sevoflurane and be used the Aysis as the anesthetic machine.

Timeline

• Start date: 2012-08-01
• Primary completion: 2013-02-01
• Completion: 2013-02-01
• First posted: 2012-10-04
• Last updated: 2014-11-27
• Results posted: 2014-11-27

Locations

1 site across 1 country: Japan