NCT01697852

The Combined Use of Indoor Residual Spraying (IRS) and Long-lasting Insecticidal Nets (LLINs) for Malaria Prevention

Cluster Randomised Trial to Compare Effectiveness of the Combined Use of Indoor Residual Spraying (IRS) and Long-lasting Insecticidal Nets (LLINs) to LLINs Alone for Malaria Prevention in Muleba District, Kagera Region, Tanzania

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 22,300 (estimated)
• Sponsor: London School of Hygiene and Tropical Medicine · Academic / Other
• Sex: All
• Age: 6 Months – 14 Years
• Healthy volunteers: Accepted

Summary

The study is a cluster randomised trial to compare the effectiveness of indoor residual spraying (IRS) combined with the use of long lasting insecticidal nets (LLINs) with the effectiveness of LLINs alone for preventing malaria infection and morbidity. The primary outcome measure is prevalence of parasitaemia and anaemia in children aged 0.5-10 years, measured in cross sectional surveys. Secondary outcomes include relative population density for each mosquito vector species, malaria transmission as measured by entomological inoculation rates (EIR) by mosquito vector species, monitoring of resistance markers including kdr, and user acceptability of LLINs compared with IRS. Findings from this study are expected to inform decision making so that resource utilization can be optimised.

Conditions

• Malaria

Interventions

Type	Name	Description
OTHER	Indoor residual spraying with bendiocarb	2 rounds of indoor residual spraying with bendiocarb insecticide, 4 months apart
OTHER	LLIN by universal coverage campaign	Long lasting Insecticide treated mosquito net

Timeline

• Start date: 2011-01-01
• Primary completion: 2012-11-01
• Completion: 2012-12-01
• First posted: 2012-10-02
• Last updated: 2012-10-03

Locations

1 site across 1 country: Tanzania