NCT01690039

Influence of Polymorphisms in the ATP6V1 Gene of the V-ATPase on the Development of Incomplete Distal Renal Tubular Acidosis

Comparison of Furosemide/Fludrocortisone With Ammonium Chloride Loading Test in the Diagnosis of Incomplete dRTA in Kidney Stone Formers

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 170 (actual)
• Sponsor: Insel Gruppe AG, University Hospital Bern · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Purpose 1. To compare the performance of the two currently employed urinary acidifications tests in stone formers, the furosemide/fludrocortisone and ammonium chloride loading test. 2. To study the impact of polymorphisms in the genes ATP6V1B1, ATP6V0A4 and SLC4A1 on urinary acidification in stone formers.

Conditions

• Acidosis, Renal Tubular
• Nephrolithiasis
• Vacuolar Proton-Translocating ATPases

Interventions

Type	Name	Description
DRUG	Furosemide-Fludrocortisone-Test (test for urinary acidification)	The presence of a lack of urinary acidification will be assessed by an appropriate test in all patients.

Timeline

• Start date: 2012-09-01
• Primary completion: 2016-12-31
• Completion: 2017-05-12
• First posted: 2012-09-21
• Last updated: 2018-10-09

Locations

1 site across 1 country: Switzerland