Trials / Unknown

UnknownNCT01687686

Differential Effects of Lipids on Cardiovascular Diseases: A CALIBER Study

Differential Effects of Total Cholesterol, Non-HDL Cholesterol and Triglycerides on Initial Presentation of Specific Cardiovascular Diseases (a CALIBER Study)

Status: Unknown
Phase: —
Study type: Observational
Enrollment: 175,872 (actual)

Sponsor: University College, London · Academic / Other
Sex: All
Age: 30 Years
Healthy volunteers: Not accepted

Summary

The role of lipids as risk factors for cardiovascular events is well-documented, although events studied have largely been broad classes without specific detail. This study will examine a more refined set of endpoints.

Detailed description

The role of lipids (cholesterol and triglycerides) as risk factors for cardiovascular events is well-documented. The Emerging Risk Factors Collaboration found approximately log-linear adjusted associations of cholesterol concentrations with risks of first-time non-fatal myocardial infarction; coronary heart disease (CHD) death; ischaemic, haemorrhagic and unclassified stroke. They also found that triglycerides concentration was not independently related with CHD risk after controlling for HDL cholesterol (HDL-C), non-HDL-C, and other standard risk factors. The Prospective Studies Collaboration found that Higher HDL-C and lower non-HDL-C levels were approximately independently associated with lower ischaemic heart disease mortality. By focusing on broad outcomes these large meta-analyses conflate the association between development of the different cardiovascular disease (CVD) phenotypes, disease progression and mortality from cardiovascular causes. With linked electronic health records, we have the potential for a cohort with sufficient size and clinical detail to investigate the association between lipid concentrations and initial presentation of a range of CVD phenotypes across cerebral, coronary, abdominal and peripheral arterial circulations.

Conditions

Timeline

Start date: 2001-01-01
Primary completion: 2010-03-01
Completion: 2012-12-01
First posted: 2012-09-19
Last updated: 2012-09-19

Locations

1 site across 1 country: United Kingdom

Source: ClinicalTrials.gov record NCT01687686. Inclusion in this directory is not an endorsement.