NCT01667055

The Diagnosis of Beta-lactam Hypersensitivity in Thailand

The Optimized Diagnostic Methods for the Confirmation of Beta-lactam Hypersensitivity in Thailand

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 500 (actual)
• Sponsor: Chulalongkorn University · Academic / Other
• Sex: All
• Age: 7 Years
• Healthy volunteers: Not accepted

Summary

The true prevalence of drug allergy in patients with a history of beta-lactam hypersensitivity will be determined by using commercially available standard skin test reagents and the diagnostic agents available in Thailand. We hypothesize that only minority of patients with such a history are truly allergic.

Detailed description

Patients with a history of beta-lactam hypersensitivity will be evaluated by the standard skin test reagents (major and minor determinants of penicillin, amoxicillin, and clavulanic if applicable), and intravenous forms of beta-lactam antibiotics . Diagnostic values of the measurement of specific Immunoglobulin E to penicillin/aminopenicillin and skin test reagents currently available in Thailand will be comparatively analyzed with the standard skin test reagents. The measurement of drug-induced interferon-gamma releasing cells will be measured in patients with a history of non-immediate reaction.

Conditions

• Penicillin Allergy
• Aminopenicillin Allergy
• Beta Lactam Adverse Reaction

Timeline

• Start date: 2012-06-01
• Primary completion: 2018-12-01
• Completion: 2018-12-01
• First posted: 2012-08-17
• Last updated: 2019-10-29

Locations

1 site across 1 country: Thailand