NCT01666964

Hormone Deficiency After Brain Injury During Combat

Prevalence of Hypopituitarism Following Combat-related Traumatic Brain Injury in a Military Population

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 200 (estimated)
• Sponsor: Walter Reed National Military Medical Center · Federal
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

We would like to ascertain the prevalence of hypopituitarism after combat-related TBI. This will lead to enhanced awareness, recognition, and treatment of hypopituitarism, which can have life-saving ramifications and enhance quality of life and rehabilitation efforts in our combat veterans.

Detailed description

The prevalence of hypopituitarism after combat-related traumatic brain injury (TBI) is currently unknown. Recent civilian data on TBI show the prevalence of any pituitary hormone deficiency is as high as 80% after 12 months. While the military prevalence of hypopituitarism can be extrapolated from civilian data, a major limitation is the notably different mechanism of injury (i.e., blast) for military personnel compared to civilians (i.e., assaults, traffic accidents and falls). Little is known about the effect of shockwaves from a blast injury on central nervous system tissue, and due to the unique nature of blast-related TBI, the prevalence of pituitary dysfunction in affected service members may significantly differ from nonmilitary subjects in prior studies.

Conditions

• Traumatic Brain Injury
• Hypopituitarism

Interventions

Type	Name	Description
OTHER	Blast Traumatic Brain Injury	Exposure during combat to blast-wave mediated Traumatic Brain Injury

Timeline

• Start date: 2012-10-01
• Primary completion: 2014-12-01
• Completion: 2015-05-01
• First posted: 2012-08-16
• Last updated: 2012-08-16

Locations

1 site across 1 country: United States