Trials / Completed
CompletedNCT01649128
Screening for Preeclampsia With Various Markers in Low-risk Pregnancy Populations
Screening Models for Early Detection of Late-onset Preeclampsia With Various Markers in Low-risk Pregnancy Populations
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 262 (actual)
- Sponsor
- CHA University · Academic / Other
- Sex
- Female
- Age
- 20 Years – 39 Years
- Healthy volunteers
- Not accepted
Summary
For the prediction of late-onset preeclampsia (PE) in low risk women, the investigators established a cut-off value for sFlt-1/PlGF ratio and evaluated the combination models of Elecys, second trimester uterine artery (UtA) doppler, and fetoplacental proteins for Down syndrome screening.
Detailed description
A prospective study was carried on in Cha hospital. Serum samples for Down syndrome screening were assayed to estimate pregnancy-associated plasma protein-A (PAPP-A), alpha-fetoprotein , unconjugated estriol, human chorionic gonadotrophin , and inhibin-A. Women screened for Down syndrome were offered UtA Doppler at 20-24 weeks of gestation and then collected serial serum samples for sFlt-1/PlGF ratio at two time points (24-27 and 34-37 weeks' gestation).
Conditions
Timeline
- Start date
- 2009-08-01
- Primary completion
- 2011-12-01
- Completion
- 2011-12-01
- First posted
- 2012-07-25
- Last updated
- 2012-07-25
Source: ClinicalTrials.gov record NCT01649128. Inclusion in this directory is not an endorsement.