NCT01635010

Obstructive Sleep Apnea in the Absence of Metabolic Syndrome

Obstructive Sleep Apnea in the Absence of Metabolic Syndrome: Pulse Wave Velocity, Inflammatory and Oxidative Stress Markers

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 34 (actual)
• Sponsor: Associação Fundo de Incentivo à Pesquisa · Academic / Other
• Sex: Male
• Age: 25 Years – 60 Years
• Healthy volunteers: Accepted

Summary

Obstructive Sleep Apnea (OSA) is commonly associated with factors that increase cardiovascular risk, including Metabolic Syndrome (MS). There is a lack of well-controlled clinical studies investigating the independent effects of OSA in the development of cardiovascular disease, especially evaluating jointly mechanisms involved in these disorders such as inflammatory response, oxidative stress and vascular changes. The investigators hypothesized that in the absence of MetS, the mechanisms involved on cardiovascular consequences in OSA patients would be less important. The purpose of this study is to analyze the effects of OSA in the absence of MS, on inflammatory, oxidative stress and vascular markers; to verify the influence of excessive daytime sleepiness (EDS) on the same parameters; and additionally verify the effects of nasal continuous positive airway pressure (nCPAP)in theses parameters.

Conditions

• Obstructive Sleep Apnea

Interventions

Type	Name	Description
PROCEDURE	continuous positive airway pressure (CPAP)	CPAP pressure is individually prescript according to polysomnography for CPAP titration

Timeline

• Start date: 2008-12-01
• Primary completion: 2011-12-01
• Completion: 2011-12-01
• First posted: 2012-07-06
• Last updated: 2012-07-06

Locations

1 site across 1 country: Brazil