NCT01627236

Efficacy of Short-term Immunosuppressive Therapy and Anti-allergenic Therapy in Severe Acute Exacerbation of Chronic Hepatitis B

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 120 (estimated)
• Sponsor: Third Affiliated Hospital, Sun Yat-Sen University · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

The investigators will investigate the clinicopathological features of chronic hepatitis B patients with severe exacerbation selected by uniform criteria, and treated with early introduction or reintroduction of corticosteroids and anti-allergenic therapy, in order to clarify the benefits and limitations of the effects of corticosteroids and anti-allergenic therapy for amelioration of clinically severe exacerbation of chronic hepatitis B. The investigators also observe the immune index in the change before and after the treatment, in order to searching for some prognostic index.

Conditions

• Severe Acute Exacerbation of Chronic Hepatitis B

Interventions

Type	Name	Description
DRUG	methylprednisolone	methylprednisolone 1mg/kg intravenous drip qd，for 3 days glucocorticoid

Timeline

• Start date: 2012-12-01
• Primary completion: 2014-08-01
• Completion: 2014-11-01
• First posted: 2012-06-25
• Last updated: 2013-10-10

Locations

1 site across 1 country: China