NCT01623934

Role of Adipokines in Glucose Regulation During Pregnancy and in Fetal Development

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 1,034 (actual)
• Sponsor: Université de Sherbrooke · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study includes 2 phases. During phase 1, pregnant women are followed over the course of pregnancy. The phase 2 is a follow-up of the mother-child dyad at 3, 5 and 10-12 year after delivery. The purpose of this phase 1 is to : * assess the contribution and interactions of adipokines in the development of insulin resistance during pregnancy and gestational diabetes; * assess levels of maternal adipokines as determinants of development and fetal growth; * determine the genetic variations that influence levels of adipokines and glucose regulation during pregnancy and in newborns. The purpose of this phase 2 is to: * identify DNA methylation variations at birth that are predictive of childhood overweight/obesity. * identify maternal characteristics associated with DNA methylation variations predictive of childhood overweight/obesity. * establish whether the loci predictive of childhood overweight/obesity at birth are still differentially methylated at 5 years of age (samples collected at 5 years of age). * identify DNA methylation variations at birth that are predictive of childhood neurodevelopment problems at 3, 5 and 10 years of age.

Conditions

• Gestational Diabetes
• Insulin Resistance
• Obesity Prevention

Timeline

• Start date: 2010-01-01
• Primary completion: 2025-09-01
• Completion: 2025-09-01
• First posted: 2012-06-20
• Last updated: 2024-10-18

Locations

1 site across 1 country: Canada