NCT01610154

Contribution of Pancreatic αcells Function to Blood Glucose Regulation in Chinese Type 2 Diabetics- the Effect of Sitagliptin on Glucagon Secretion, Insulin Secretion and Insulin Resistance in Chinese Type 2 Diabetics

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 85 (actual)
• Sponsor: Guangwei Li · Academic / Other
• Sex: All
• Age: 25 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

1. The purpose of this study is to determine whether Sitagliptin therapy suppress glucagon release and improve glucose control in Chinese type 2 diabetic. 2. There are different effects of Sitagliptin therapy on blood glucose regulation, pancreatic alpha \& beta cell function are different in lean (BMI\<25) and overweight (BMI\>25) Chinese type 2 diabetics. 3. The purpose of this study is to determine whether glucagon release may contribute over 30% to the hyperglycemia in Chinese type 2 diabetics.

Conditions

• Insulin Secretion
• Insulin Resistance

Interventions

Type	Name	Description
DRUG	Sitagliptin	Sitagliptin 100 mg QD for 12 weeks

Timeline

• Start date: 2012-10-01
• Primary completion: 2014-08-01
• Completion: 2015-06-01
• First posted: 2012-06-01
• Last updated: 2017-05-11
• Results posted: 2017-04-04

Locations

1 site across 1 country: China