NCT01608516

Multimodal Imaging Assessment of the Inflammatory Atheromatous Plaque

Multimodal Assessment of the Inflammatory Atheromatous Plaque : Comparison Between 68Ga-NODAGA-RGD PET/CT, 18F-FDG PET/CT, MRI AND US

• Status: Recruiting
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: University of Lausanne Hospitals · Academic / Other
• Sex: All
• Age: 18 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

The present study aims at assessing the ability of 68Ga-NODAGA-RGD PET/CT for the detection of inflammatory atheromatous plaques in the carotid arteries, compared to 18F-FDG PET/CT, MRI and US and to determine the contribution of each imaging technique. Current gold standard for inflammation is histopathology. Hypothesis : 68Ga-NODAGA-RGD might give a better initial evaluation of patients with atheromatous plaques in the carotid artery eligible for endarterectomy.

Detailed description

Patients with indication for endarterectomy will be presented the present protocol. If inclusion criteria are fulfilled, patients will have a 18F-FDG PET/CT + carotid US performed 6 to 2 days before endarterectomy and 68Ga-NODAGA-RGD PET/CT + MRI performed the day before endarterectomy. Histopathological sample will be analyzed to measure plaque inflammation. All imaging results and histopathology results will be pooled and compared.

Conditions

• Inflammation
• Atheromatous Plaques
• Carotid Artery Diseases

Interventions

Type	Name	Description
DRUG	68Ga-NODAGA-RGD PET/CT	200 MBq 68 Ga-NODAGA-RGD will be administered i.v. and images centred on the carotid area acquired

Timeline

• Start date: 2012-04-01
• Primary completion: 2024-12-01
• Completion: 2024-12-01
• First posted: 2012-05-31
• Last updated: 2024-06-20

Locations

1 site across 1 country: Switzerland