NCT01606488

Effects of Brain Beta-Amyloid on Postoperative Cognition

Effects of Brain Beta Amyloid on Postoperative Cognition and 18F-AV-45-A14: Clinical Evaluation of Florbetapir F 18 (18F-AV-45)

• Status: Active Not Recruiting
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 66 (actual)
• Sponsor: University of California, San Francisco · Academic / Other
• Sex: All
• Age: 65 Years
• Healthy volunteers: Not accepted

Summary

Postoperative cognitive decline (POCD) affects up to 50% of non-cardiac surgical patients greater than or equal to 65 years of age. This study will test the hypothesis that preoperative presence of brain beta-amyloid plaques in non-demented subjects increases postoperative cognitive decline (POCD) in elderly subjects scheduled for hip or knee replacement. The investigators hypothesize that preoperative beta-amyloid plaques will predict postoperative cognitive decline.

Conditions

• Postoperative Cognitive Dysfunction

Interventions

Type	Name	Description
DRUG	Florbetapir F 18 (18F-AV-45)	Single IV bolus injection of 370 MBq (10mCi) florbetapir will be administered approximately 50 minutes prior to a 10 minute PET scan.
OTHER	no intervention

Timeline

• Start date: 2012-05-01
• Primary completion: 2026-06-01
• Completion: 2026-06-01
• First posted: 2012-05-25
• Last updated: 2025-05-01

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study