Trials / Completed

CompletedNCT01604486

Natural Ischaemic Preconditioning Before First Myocardial Infarction

Natural Ischaemic Preconditioning Before First Myocardial Infarction: an Analysis of Prospectively Collected UK Electronic Primary Care Records Linked to the National Registry of Acute Coronary Syndromes

Status: Completed
Phase: —
Study type: Observational
Enrollment: 16,000 (actual)

Sponsor: London School of Hygiene and Tropical Medicine · Academic / Other
Sex: All
Age: 18 Years
Healthy volunteers: Not accepted

Summary

There is a sharp rise in the rate of coronary heart disease diagnoses and chest pain consultations in the 90 days before a first heart attack. There is some evidence that chest pain and angina symptoms in this period have a beneficial effect on heart attack outcomes in hospital and shortly after discharge. However, the available evidence is lacking in three key areas. First it is based on a retrospective patient report of symptoms after the heart attack has occurred; this means that patients are required to survive their heart attack and may make errors when reporting prior symptoms. Second, evidence for an effect on longer term outcomes, and coronary outcomes in particular (e.g. coronary death, further heart attacks) are unknown. Third, there is conflicting evidence that these effects might differ by age, in men and women, and according to treatment in hospital. The investigators hope to address the limitations in the evidence by performing a large, prospective study of the occurrence, timing and effect of different types of symptoms and disease diagnoses occurring before heart attack. The investigators hypothesise that prospectively collected, clinical measures of chest pain symptoms and cardiovascular diagnoses in primary care will have a beneficial effect on short term coronary mortality and may have a beneficial effect on longer term coronary outcomes.

Conditions

Timeline

Start date: 2009-09-01
Primary completion: 2013-12-01
Completion: 2013-12-01
First posted: 2012-05-23
Last updated: 2015-10-02

Locations

1 site across 1 country: United Kingdom

Source: ClinicalTrials.gov record NCT01604486. Inclusion in this directory is not an endorsement.