NCT01603251

Trial of Artemether-Lumefantrine Alone and in Combination With Ivermectin to Reduce Post-Treatment Malaria Transmission

A Double Blind Randomized Controlled Trial of Artemether-Lumefantrine Alone and in Combination With Ivermectin to Reduce Post-Treatment Malaria Transmission

• Status: Completed
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 120 (actual)
• Sponsor: London School of Hygiene and Tropical Medicine · Academic / Other
• Sex: All
• Age: 15 Years – 25 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to determine the safety and impact of ivermectin, administered as single or repeated dose, in combination with artemether-lumefantrine in reducing the proportion of mosquitoes that survive and become infected after feeding on a blood meal from a malaria-infected individual.

Conditions

• Malaria

Interventions

Type	Name	Description
DRUG	Artemether-lumefantrine combination	Artemether-Lumefantrine (AL)combination; a placebo is given together with the first and fifth dose of AL
DRUG	Artemether-lumefantrine combination + single dose Ivermectin	Artemether-lumefantrine (AL) combination + Ivermectin (200ug/kg) given once together with the first dose of AL. A placebo is given together with the fifth dose of AL.
DRUG	Artemether-lumefantrine combination + repeated dose Ivermectin	Artemether-lumefantrine (AL) combination + Ivermectin (200ug/kg) given together with the first and fifth dose of AL.

Timeline

• Start date: 2013-01-01
• Primary completion: 2013-04-01
• Completion: 2013-04-01
• First posted: 2012-05-22
• Last updated: 2013-04-18

Locations

1 site across 1 country: Burkina Faso