NCT01600404

Effects of Antimuscarinics on Cognition in Spinal Cord Injury

Effects of Antimuscarinic Drugs on the Cognition of Patients With Acute Spinal Cord Injury

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 32 (actual)
• Sponsor: Swiss Paraplegic Research, Nottwil · Network
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Prospective evaluation of the cognitive function of in-house patients suffering from an acute traumatic spinal cord injury before and three months after the initiation of antimuscarinic treatment. The following hypothesis will be tested: Antimuscarinic treatment results in significantly worse cognitive test results three months after traumatic spinal cord injury compared to the pre-treatment results and the results of the control group.

Detailed description

There will be two groups: 1) patients receiving antimuscarinic treatment 2) patients without antimuscarinic treatment (control). The control group will be investigated in order to determine the effects of traumatic spinal cord injury on cognition and the natural history of potential cognitive impairment within the first three months after spinal cord injury. Six to eight weeks after traumatic spinal cord injury, patients are examined in order to determine the type of neurogenic bladder dysfunction they are suffering from. Patients suffering from an overactive bladder will receive antimuscarinic treatment in order to prevent high urine storage and voiding pressures, that put the kidneys at risk. Prior to the urologic examination, patients fulfilling inclusion criteria will be contacted. If informed consent is given, cognitive function will be evaluated in both patient groups using different standard neuropsychologic tests. The same neuropsychologic tests will be repeated three months later. Evaluation will take place under standardized conditions (e.g. time of day). Furthermore,different factors influencing cognition, e.g. depression, pain, medication, will be assessed at the beginning and end of the study.

Conditions

• Mild Cognitive Impairment
• Spinal Cord Injuries

Interventions

Type	Name	Description
DRUG	antimuscarinic treatment

Timeline

• Start date: 2011-12-01
• Primary completion: 2015-11-01
• Completion: 2015-11-01
• First posted: 2012-05-17
• Last updated: 2015-11-17

Locations

1 site across 1 country: Switzerland