NCT01594047

Perioperative Opioid-induced Hyperalgesia and Its Prevention With Ketamine and Methadone

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 113 (actual)
• Sponsor: Fondazione IRCCS Istituto Nazionale dei Tumori, Milano · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

Background: In perioperative period inhibition of N-Methyl-D-Aspartate receptor prevents opioid-induced hyperalgesia and reduce postoperative opioid requirement after abdominal surgery. Methadone is both a µ-opioid receptor agonist like Morphine and a N-Methyl-D-Aspartate antagonist. Study Aim. To evaluate the efficacy of intraoperative Ketamine and postoperative Methadone analgesia in preventing opioid-induced hyperalgesia after abdominal surgery.

Detailed description

not desired

Conditions

• Post Operative Pain
• Hyperalgesia

Interventions

Type	Name	Description
DRUG	ketamine infusion	Ketamine infusion scheme: 5mcg/Kg/min from induction od anaesthesia for 10 min, than 2,5mcg/Kg/min for 20 min and than 2 mcg/Kg/min to the end of surgery
DRUG	Methadone PCA	Methadone administered by a PCA system (dose 2 mg, lock-out 12min.)

Timeline

• Start date: 2009-12-01
• Primary completion: 2012-06-01
• Completion: 2014-08-01
• First posted: 2012-05-08
• Last updated: 2025-10-01
• Results posted: 2023-10-02

Locations

1 site across 1 country: Italy