NCT01588561

Nicotine Related Brain Activity: The Influence of Smoking History and Blood Nicotine Levels

Nicotine Related Brain Activity: The Influence of Smoking History and Blood Nicotine Levels, an Exploratory Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 15 (actual)
• Sponsor: Mclean Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

In this study, we sought to explore brain activity in nicotine-dependent men in response to acute intravenous nicotine using pharmacological magnetic resonance imaging (phMRI).

Detailed description

phMRI was used to evaluate brain activity in response to 1.5 mg/70 kg intravenous nicotine or saline. The nicotine and saline were administered on different visits. The time courses of individual subjects' nicotine levels were used as regressors to assess neural activity relating to the infusions. The influence of Smoking history and physiological measures on the response to nicotine were also investigated.

Conditions

• Nicotine Dependence

Interventions

Type	Name	Description
DRUG	Intravenous Nicotine	Subjects received a single infusion of nicotine, 1.5 mg/70kg (New England Compounding Center, Framingham, MA), administered over 1 minute into the antecubital vein 10 minutes into their MRI scans.
OTHER	Saline - placebo	Subjects received a single infusion of saline, administered over 1 minute into the antecubital vein 10 minutes into their MRI scans.

Timeline

• Start date: 2005-10-01
• Primary completion: 2015-07-01
• Completion: 2015-09-01
• First posted: 2012-05-01
• Last updated: 2017-08-31
• Results posted: 2017-08-31

Locations

1 site across 1 country: United States