Clinical Trials Directory

Trials / Completed

CompletedNCT01586104

Intensity-Modulated Radiation Therapy in Treating Younger Patients With Lung Metastases

Cardiac-Sparing Whole Lung IMRT in Children and Young Adults With Lung Metastases: A Feasibility Study

Status
Completed
Phase
N/A
Study type
Interventional
Enrollment
20 (actual)
Sponsor
Ann & Robert H Lurie Children's Hospital of Chicago · Academic / Other
Sex
All
Age
1 Year – 29 Years
Healthy volunteers
Not accepted

Summary

This pilot clinical trial studies intensity-modulated radiation therapy (IMRT) in treating younger patients with lung metastases. Specialized radiation therapy that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue.

Detailed description

OBJECTIVES: I. To demonstrate the feasibility of delivering cardiac-sparing IMRT in a multi-institutional setting with central quality control for children and young adults with metastatic tumors in the lungs. II. To prospectively determine the dosimetric advantages of whole lung IMRT treatment over standard whole lung irradiation by comparing treatment plans and different organ dose-volume histograms such as lungs, heart, thyroid gland, liver etc. in all patients enrolled in this study. III. To determine the short-term efficacy (lung-metastases free survival) and acute tolerance of whole lung IMRT at a minimum period of six months after IMRT. OUTLINE: Patients undergo cardiac-sparing whole lung IMRT. After completion of study treatment, patients are followed up for 1-5 years.

Conditions

Interventions

TypeNameDescription
RADIATIONintensity-modulated radiation therapyUndergo cardiac-sparing whole lung IMRT

Timeline

Start date
2011-02-01
Primary completion
2016-06-02
Completion
2016-06-02
First posted
2012-04-26
Last updated
2025-02-10
Results posted
2025-02-10

Locations

7 sites across 1 country: United States

Source: ClinicalTrials.gov record NCT01586104. Inclusion in this directory is not an endorsement.