NCT01551667

Immune Response of Patients With Chronic, Staphylococcus Aureus-infected Wounds

Observational and Comparative Study on the Immune Response of Patients With Chronic, Staphylococcus Aureus-infected Wounds (Localized Infections Versus Bacteremia)

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 69 (actual)
• Sponsor: Centre Hospitalier Universitaire de Nīmes · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The primary objective of this study is to detect differences in anti-S. aureus antibody assays (IgM, IgA, IgG and its subclasses) between (1) a group of patients with bacteremia due to a chronic wound (cases) and (2) a group of patients with localized chronic wound infections (control).

Detailed description

Secondary objectives include: * To propose a diagnostic marker of bacteraemia based on the detection of anti-S. aureus by xMAP technology * To evaluate the kinetics of the humoral immune response to S. aureus in patients with bacteraemia * To evaluate the virulence of S. aureus isolated from chronic, infected wounds * To enrich the Nîmes University Hospital biobank * To evaluate the prevalence of different antibodies within each group

Conditions

• Diabetic Foot
• Foot Ulcer
• Leg Ulcer
• Bacteremia
• Infection

Interventions

Type	Name	Description
BIOLOGICAL	Antibody assays for S. aureus	Antibody assays for S. aureus at Day 0, Day 2, Day 4, Day 7, Day 30 and Month 6.
BIOLOGICAL	Basic blood work	Hemogramme + CRP on Days 0, 2, 4 and 7

Timeline

• Start date: 2012-11-01
• Primary completion: 2016-03-01
• Completion: 2016-03-01
• First posted: 2012-03-13
• Last updated: 2016-04-06

Locations

6 sites across 1 country: France