NCT01535456

FLT-PET Imaging for MDS

A Pilot Study for Using 18F-FLT PET Imaging To Assess Response In Patients With Myelodysplastic Syndrome (MDS) Being Treated With 5-azacitidine

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 1 (actual)
• Sponsor: University of Wisconsin, Madison · Academic / Other
• Sex: All
• Age: 18 Years – 100 Years
• Healthy volunteers: Not accepted

Summary

The main purpose of this study is to see if this tracer can be used to determine how well chemotherapy is working in patients with certain types of leukemia.

Detailed description

Primary objectives 1. To evaluate if FLT-PET uptake shows variation during the treatment course in subjects with MDS being treated with 5-azacitidine therapy Secondary objectives 2. To assess FLT-PET uptake heterogeneity within given subjects being treated with 5-azacitidine therapy 3. To generate preliminary data regarding correlation between FLT-PET imaging parameters and clinical responses based on bone marrow aspirate/biopsy

Conditions

• AML
• MDS

Interventions

Type	Name	Description
PROCEDURE	FLT-PET scans	FLT-PET scans prior to treatment, after Cycle 1, after Cycle 4

Timeline

• Start date: 2012-07-01
• Primary completion: 2013-07-01
• Completion: 2014-03-01
• First posted: 2012-02-17
• Last updated: 2019-12-13

Locations

1 site across 1 country: United States