NCT01530230

ST- Depression on Electrocardiogram During Caesarean Section in Regional Anaesthesia in Women With Preeclampsia

Randomised Study on Cardiac Effects of Oxytocin During Caesarean Section in Preeclamptic Women

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 25 (actual)
• Sponsor: Uppsala University Hospital · Academic / Other
• Sex: Female
• Age: 18 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

The investigators examined whether there was a difference in the occurrence of ST depressions after injection of five or ten units of oxytocin, in preeclamptic patients delivered by caesarean section (CS) under regional anesthesia.

Detailed description

ST depression on electrocardiograms has been reported in healthy women undergoing cesarean section in regional anesthesia. The investigators examined whether there was a difference in the occurrence of electrocardiogram changes suggestive of myocardial ischemia (ST depressions) in preeclamptic patients randomized to five or ten units of oxytocin during cesarean section with regional anesthesia. In a double-blind randomized controlled study preeclamptic patients undergoing cesarean section under spinal anesthesia were randomized to 5 or 10 units of oxytocin, given as an intravenous bolus. A Holter monitor was used to record electrocardiograms. Non-invasive blood pressure and heart rate were monitored.

Conditions

• Preeclampsia

Interventions

Type	Name	Description
DRUG	oxytocin	Intravenous bolus dose given during 1 minute after clamping of the umbilical cord

Timeline

• Start date: 2005-11-01
• Primary completion: 2008-04-01
• Completion: 2008-04-01
• First posted: 2012-02-09
• Last updated: 2012-02-13

Locations

1 site across 1 country: Sweden