NCT01528956

Studying Genes in Samples From Younger Patients With Adrenocortical Tumor

Using New Approaches for Genomics Studies in Pediatric Adrenocortical Tumors: Whole Genome Sequencing; Deep Sequencing; miRNA; methDNA and SNP 6.0

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 10 (estimated)
• Sponsor: Children's Oncology Group · Network
• Sex: All
• Age: 21 Years
• Healthy volunteers: Not accepted

Summary

RATIONALE: Studying samples of blood and tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This research trial studies genes in samples from younger patients with adrenocortical tumor.

Detailed description

OBJECTIVES: * To perform whole-genome sequencing, deep sequencing, micro RNA analysis, methylation status, copy number variation analysis, and single-nucleotide polymorphisms (SNPs) analysis in pediatric adrenocortical tumors and compare those results to those of the same patient's normal cells. OUTLINE: Archived tumor and blood samples are analyzed for whole-genome sequencing, deep sequencing, micro RNA , methylation status, copy variation, and single-nucleotide polymorphisms. Results are then compared with patients' normal cells.

Conditions

• Adrenocortical Carcinoma

Interventions

Type	Name	Description
GENETIC	DNA methylation analysis
GENETIC	RNA analysis
GENETIC	gene expression analysis
GENETIC	nucleic acid sequencing
GENETIC	polymorphism analysis

Timeline

• Start date: 2012-02-01
• Primary completion: 2016-05-01
• First posted: 2012-02-08
• Last updated: 2016-05-18