NCT01525680

A Randomized Clinical Trial of Hydrocortisone Augmentation of Prolonged Exposure

Improving PTSD Outcomes in OIF/OEF Returnees: A Randomized Clinical Trial of Hydrocortisone Augmentation of Prolonged Exposure Therapy"

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Bronx VA Medical Center · Federal
• Sex: All
• Age: 18 Years – 89 Years
• Healthy volunteers: Accepted

Summary

This study seeks to examine the efficacy of hydrocortisone administration in the augmentation of the therapeutic effects of Prolonged Exposure (PE) therapy, an empirically tested treatment shown to be effective in the the treatment of posttraumatic stress disorder (PTSD). The augmentation builds on both the translation of neuroscience findings demonstrating the effects of glucocorticoids (GCs) on learning, and on empirical clinical findings from other investigators demonstrating beneficial effects of GCs in reducing traumatic memories in trauma-exposed persons.

Conditions

• Post Traumatic Stress Disorder

Interventions

Type	Name	Description
OTHER	Hydrocortisone augmented Prolonged Exposure Therapy	11 sessions of PE. 20 minutes prior to final eight sessions, 30 mg hydrocortisone is administered.
OTHER	Prolonged exposure therapy with placebo administration	11 sessions of PE. 20 minutes prior to final eight sessions, placebo is administered.

Timeline

• Start date: 2011-04-01
• Primary completion: 2015-09-01
• First posted: 2012-02-03
• Last updated: 2013-11-28

Locations

1 site across 1 country: United States