NCT01505231

Vasopressin Versus Norepinephrine for the Management of Shock After Cardiac Surgery

• Status: Unknown
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 300 (estimated)
• Sponsor: University of Sao Paulo · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Vasoplegic syndrome after cardiac surgery is a common complication after cardiac surgery, with negative impact on patient outcomes and hospital costs. Pathogenesis of vasodilatory phenomenon after cardiac surgery remains a matter of controversy. Loss of vascular tone can be partly explained by the depletion of neurohypophyseal arginine vasopressin stores. The investigators hypothesized that the use of arginine vasopressin would be more effective on treatment of shock after cardiac surgery than norepinephrine, decreasing the composite end point of mortality and severe morbidity.

Conditions

• Shock

Interventions

Type	Name	Description
DRUG	Vasopressin	Blinded Vasopressin will be started if there is persistent hypotension, characterized by mean arterial pressure \<65 mmHg after fluid replacement.
DRUG	Norepinephrine	Blinded Norepinephrine will be started if there is persistent hypotension, characterized by mean arterial pressure \<65 mmHg after fluid replacement

Timeline

• Start date: 2012-01-01
• Primary completion: 2013-02-01
• Completion: 2013-05-01
• First posted: 2012-01-06
• Last updated: 2013-02-12

Locations

1 site across 1 country: Brazil