NCT01501786

Does Ketamine Attenuate Depression of Respiratory and Cardiac Functions

The Effect of Small-dose Ketamine on Depression of Respiratory and Cardiac Functions Caused by Propofol in Pediatric Cardiac Catheterization

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 150 (actual)
• Sponsor: Ibaraki Children's Hospital · Academic / Other
• Sex: All
• Age: 6 Months – 10 Years
• Healthy volunteers: Not accepted

Summary

Normal cardiac and respiratory functions should be maintained during pediatric cardiac catheterization. Propofol has become a popular choice for sedation in children, however, it depresses cardiac and respiratory functions. Some investigators reported that ketamine attenuates its depressant effect, but it remains unclear whether ketamine reduces cardiac and respiratory depression caused by propofol in pediatric cardiac catheterization.

Conditions

• Congenital Heart Disease
• Sedated for Cardiac Catheterization

Interventions

Type	Name	Description
DRUG	control	propofol 8mg/kg/h saline 0.24 ml/kg/h
DRUG	Ket10	propofol 6.4 mg/kg/h ketamine 10 microg/kg/min
DRUG	Ket20	propofol 4.8 mg/kg/h ketamine 20 microg/kg/min

Timeline

• Start date: 2012-01-01
• Primary completion: 2013-05-01
• Completion: 2013-05-01
• First posted: 2011-12-29
• Last updated: 2013-07-30

Locations

1 site across 1 country: Japan