NCT01491867

Continuous Intraocular Pressure (IOP) Measurement and Ability to Detect Treatment Effect

Evaluation of Continuous IOP Measurement and the Influence of Drug Induced IOP Decrease on the Measurement

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 9 (actual)
• Sponsor: Semmelweis University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Continuous intraocular pressure (IOP) measurement with a contact lens sensor may provide more information on the drug-related IOP change than 24-hour IOP measurement with Goldmann applanation tonometry (GAT.

Detailed description

* Participants are washed ot from all glaucoma medication for 6 weeks * one eye per participant is investigated (study eye) * 24-h intraocular pressure (IOP) curve is obtained with Goldmann tonometry and Sensimed contact lens sensor tonometry twice, in 14 days * for Sensimed contact lens curves median values (in arbitrary units), for Goldmann applanation tonometry, mean and SD values are used to characterize the curves, for comparisions % changes are used for the corresponding time periods * treatment (travoprost 0.005% 1/day) is given to all eyes for 3 months 24-h Goldmann and Sensimed IOP curves are repeated * IOP curves are determined in arbitrary units and mmHg, respectively, and compared for reproducibility (untreated phase) and relative (%)change (untreated curve vs. under treatment curve) with both methods, respectively

Conditions

• Glaucoma
• Ocular Hypertension

Interventions

Type	Name	Description
DRUG	travoprost 0.003%	Instillation of travoprost 0.003% 1/die in both eyes for 3 months

Timeline

• Start date: 2011-12-01
• Primary completion: 2012-10-01
• Completion: 2012-10-01
• First posted: 2011-12-14
• Last updated: 2013-03-22

Locations

2 sites across 1 country: Hungary