NCT01484106

Cardiac Output Monitoring Managing Intravenous Therapy (COMMIT) to Treat Emergency Department Severe Sepsis

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 65 (actual)
• Sponsor: Cheetah Medical Inc. · Industry
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The primary objective of this study is to test whether a fluid resuscitation protocol guided by non-invasive hemodynamic measures reduces the progression of organ dysfunction (defined by an increase in the Serial Organ Failure Assessment Score ≥ 1 over the first 72 hours) in sepsis patients presenting to the Emergency Department without evidence of shock.

Conditions

• Sepsis

Interventions

Type	Name	Description
OTHER	Fluid Resuscitation	In the Treatment group, this information will be used in a specific 4-hour treatment algorithm to guide fluid administration that is summarized in Figure 1. The information provided by the NICOM in response to the fluid bolus will be used to assess whether the subject is "fluid responsive" (FR).
OTHER	Standard of Care	Standard of Care

Timeline

• Start date: 2011-11-01
• Primary completion: 2014-08-01
• Completion: 2014-08-01
• First posted: 2011-12-02
• Last updated: 2021-07-21

Locations

12 sites across 1 country: United States