NCT01480765

Preventing Pain After Heart Surgery

Prospective, Double-blinded, Randomised, Placebo Controlled Trial of Pre-emptive Analgesia to Prevent Pain Following Sternotomy for Cardiac Surgery.

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 150 (actual)
• Sponsor: Barts & The London NHS Trust · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The use of pre-emptive analgesia to prevent pain following sternotomy for cardiac surgery

Conditions

• Pain
• Hyperalgesia
• Chronic Illness
• Neuropathic Pain

Interventions

Type	Name	Description
DRUG	Pregabalin	150mg (2hrs) pre operatively and twice daily post operatively for 10 days, followed by dose reduction to 75mg twice daily for 2 days and finally to 50 mg twice daily for 2 days
DRUG	Ketamine infusion	0.1mg/kg/hr for 48 hours post operatively
DRUG	Placebo capsules	Single capsule (2hrs) pre operatively and twice daily post operatively for 10 days, followed by dose reduction to single capsule twice daily for 2 days and finally to single capsule twice daily for 2 days
DRUG	Placebo infusion	Normal saline placebo intravenous infusion for 48 hours

Timeline

• Start date: 2011-12-12
• Primary completion: 2013-03-07
• Completion: 2013-03-07
• First posted: 2011-11-29
• Last updated: 2024-11-05

Locations

1 site across 1 country: United Kingdom