NCT01465308

The Effect of Honey on Xerostomia and Oral Mucositis

A Randomized Control Trial for the Effect of Honey on Radiotherapy Induced Xerostomia and Oral Mucositis in Patients With Head and Neck Cancers

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 72 (actual)
• Sponsor: Cyprus University of Technology · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine whether the use of pure honey will help in the treatment of radiation induced xerostomia and oral mucositis (symptom management)

Detailed description

Radiation-induced mucositis is a normal acute side effect of radiotherapy treatment. Exposure of ionising radiation to oral, pharyngeal and laryngeal mucosa gives rise to radiation epithelitis towards the second and third weeks of conventional fractionated radiotherapy. Likewise, salivary flow may decrease by approximately 50% during the first week of radiotherapy and upwards of 80% by the seventh week of treatment. Acute radiation-induced xerostomia is associated with inflammatory reaction. The study will include an intervention and a control group, one receiving honey prior and after the radiotherapy and the other group not receiving honey at all.

Conditions

• Head and Neck Cancer

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Honey mouthwash	The patients in the intervention group will receive honey mouthwash 15 minutes before the radiotherapy session, 15 minutes after and 6 hours after the radiotherapy session
OTHER	Normal Saline	Saline rinses 15 minutes before radiotherapy, 15 minutes after, and 6 hours after radiotherapy

Timeline

• Start date: 2011-08-01
• Primary completion: 2014-09-01
• Completion: 2014-10-01
• First posted: 2011-11-04
• Last updated: 2014-10-08

Locations

1 site across 1 country: Cyprus