NCT01460212

Magnetic Resonance Imaging Study of Cognitive-Behavior Therapy for Major Depressive Disorder

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 80 (estimated)
• Sponsor: Nanjing Medical University · Academic / Other
• Sex: All
• Age: 20 Years – 50 Years
• Healthy volunteers: Accepted

Summary

Study hypothesis: psychotherapy and SSRI treatment effect in different brain way: psychotherapy in "up to down" way and SSRI in "down to up" way. The investigators will explore this hypothesis in major depressive disorder outpatients with Magnetic Resonance Imaging analysis in this study. Patients in different groups will be treated by psychotherapy or SSRI treatment. They will all be checked with Magnetic Resonance Imaging pro and after 12 weeks of treatment.

Detailed description

Patients meeting the inclusion criteria undergo an examination that included a diagnostic interview, vision test, and psychophysiological measures. Participants then undergo the baseline fMRI scan within 48 hours, after that, they will receive psychotherapy or SSRI treatment.and returned the scan once they completed the therapy.

Conditions

• Major Depressive Disorder

Interventions

Type	Name	Description
DRUG	SSRI antidepressants	SSRI antidepressants are Selective serotonin reuptake inhibitors. They include fluoxetine (Prozac); sertraline (Zoloft); paroxetine (Paxil); citalopram (Celexa) ;escitalopram (Lexapro) and fluvoxamine (Luvox). It will be chosen according to special condition of every patient.
BEHAVIORAL	Cognitive-Behavior Therapy	The essence of CBT is a learning process through which an appropriate pattern in cognitive and behavioral could be learn and stored as memory

Timeline

• Start date: 2011-12-01
• Primary completion: 2014-12-01
• Completion: 2015-10-01
• First posted: 2011-10-26
• Last updated: 2014-09-25

Locations

1 site across 1 country: China